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Light WH, et al.  (2010) Interaction of a DNA Zip code with the nuclear pore complex promotes H2A.Z incorporation and INO1 transcriptional memory. Mol Cell 40(1):112-25

Abstract: DNA "zip codes" in the promoters of yeast genes confer interaction with the NPC and localization at the nuclear periphery upon activation. Some of these genes exhibit transcriptional memory: after being repressed, they remain at the nuclear periphery for several generations, primed for reactivation. Transcriptional memory requires the histone variant H2A.Z. We find that targeting of active INO1 and recently repressed INO1 to the nuclear periphery is controlled by two distinct and independent mechanisms involving different zip codes and different interactions with the NPC. An 11 base pair memory recruitment sequence (MRS) in the INO1 promoter controls both peripheral targeting and H2A.Z incorporation after repression. In cells lacking either the MRS or the NPC protein Nup100, INO1 transcriptional memory is lost, leading to nucleoplasmic localization after repression and slower reactivation of the gene. Thus, interaction of recently repressed INO1 with the NPC alters its chromatin structure and rate of reactivation.CI - Copyright (c) 2010 Elsevier Inc. All rights reserved.

Status: Published Type: Journal Article | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't PubMed ID: 20932479

Topics addressed in this paper

Number of different genes curated to this paper: 34

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Topics Genes linked to topics (#1 - 10 )
ASM4 ESC1 GCN5 GLE2 GSP2 HTZ1 INO1 MLP1 MLP2 NUP1
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Topics Genes linked to topics (#11 - 20 )
NUP100 NUP116 NUP120 NUP133 NUP145 NUP157 NUP170 NUP188 NUP2 NUP42
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Topics Genes linked to topics (#21 - 30 )
NUP53 NUP60 NUP84 PML39 POM152 POM34 RPO21 SAC3 SPT20 SPT7
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Primary Literature blue ball blue ball
Protein-Nucleic Acid Interactions blue ball
Regulatory Role blue ball
Strains/Constructs blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#31 - 34 )
SRC1 SUS1 SWR1 THP1
Additional Literature blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball
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