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Hacioglu E, et al.  (2010) The roles of thiol oxidoreductases in yeast replicative aging. Mech Ageing Dev 131(11-12):692-9

Abstract: Thiol-based redox reactions are involved in the regulation of a variety of biological functions, such as protection against oxidative stress, signal transduction and protein folding. Some proteins involved in redox regulation have been shown to modulate life span in organisms from yeast to mammals. To assess the role of thiol oxidoreductases in aging on a genome-wide scale, we analyzed the replicative life span of yeast cells lacking known and candidate thiol oxidoreductases. The data suggest the role of several pathways in controlling yeast replicative life span, including thioredoxin reduction, protein folding and degradation, peroxide reduction, PIP3 signaling, and ATP synthesis.CI - Copyright (c) 2010. Published by Elsevier Ireland Ltd.

Status: Published Type: Journal Article PubMed ID: 20934449

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Topics Genes linked to topics (#1 - 10 )
AHP1 ARO4 ATE1 ATP23 CAF40 CKB1 CKB2 CST26 DOT5 EPS1
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Topics Genes linked to topics (#11 - 20 )
ERG24 ERO1 ERV1 ERV2 EUG1 FIG4 GAS3 GPX1 GPX2 GRX1
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Topics Genes linked to topics (#21 - 30 )
GRX2 GRX3 GRX4 GRX5 GRX6 GRX7 GRX8 GTO1 HYR1 INP52
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Topics Genes linked to topics (#31 - 40 )
INP53 LAP3 LIP5 MAP1 MOD5 MPD1 MPD2 MXR1 MXR2 NCS2
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Topics Genes linked to topics (#41 - 50 )
NCS6 OST3 OST6 PDI1 PRX1 RTS1 SAC1 SPE2 TMA22 TRR1
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Topics Genes linked to topics (#51 - 60 )
TRX1 TRX2 TRX3 TSA1 TSA2 VAM6 VPS71 YDL034W YDR286C YER039C-A
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Topics Genes linked to topics (#61 - 66 )
YFL042C YHR035W YJL028W YLR271W YPL107W YVH1
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