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Torres EM, et al.  (2010) Identification of aneuploidy-tolerating mutations. Cell 143(1):71-83

Abstract: Aneuploidy causes a proliferative disadvantage in all normal cells analyzed to date, yet this condition is associated with a disease characterized by unabated proliferative potential, cancer. The mechanisms that allow cancer cells to tolerate the adverse effects of aneuploidy are not known. To probe this question, we identified aneuploid yeast strains with improved proliferative abilities. Their molecular characterization revealed strain-specific genetic alterations as well as mutations shared between different aneuploid strains. Among the latter, a loss-of-function mutation in the gene encoding the deubiquitinating enzyme Ubp6 improves growth rates in four different aneuploid yeast strains by attenuating the changes in intracellular protein composition caused by aneuploidy. Our results demonstrate the existence of aneuploidy-tolerating mutations that improve the fitness of multiple different aneuploidies and highlight the importance of ubiquitin-proteasomal degradation in suppressing the adverse effects of aneuploidy.CI - Copyright (c) 2010 Elsevier Inc. All rights reserved.

Status: Published Type: Journal Article PubMed ID: 20850176

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BUD9 CCT7 DCS2 DYN1 GRX4 LAG2 PRR2 RAD3 RPT1 RSP5
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Cell Growth and Metabolism yg ball
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Topics Genes linked to topics (#11 - 20 )
SAS10 SAS3 SEC31 SNT1 SRC1 SVF1 TSL1 UBI4 UBP6 UBR1
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UTP10 VPS64 YGR266W YNL234W
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