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Moses AM, et al.  (2007) Clustering of phosphorylation site recognition motifs can be exploited to predict the targets of cyclin-dependent kinase. Genome Biol 8(2):R23

Abstract: Protein kinases are critical to cellular signalling and post-translational gene regulation, but their biological substrates are difficult to identify. We show that cyclin-dependent kinase (CDK) consensus motifs are frequently clustered in CDK substrate proteins. Based on this, we introduce a new computational strategy to predict the targets of CDKs and use it to identify new biologically interesting candidates. Our data suggest that regulatory modules may exist in protein sequence as clusters of short sequence motifs.

Status: Published Type: Journal Article | Research Support, Non-U.S. Gov't PubMed ID: 17316440

Topics addressed in this paper

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ACE2 ACM1 ADY3 AIM14 ASE1 ASH1 BCK2 BEM1 BEM3 BNI4
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Topics Genes linked to topics (#11 - 20 )
BOI1 BOP3 BUD3 BUD4 CAF120 CDC15 CDC20 CDC28 CDC6 CDH1
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Topics Genes linked to topics (#21 - 30 )
CHS2 CLB5 CNN1 ECM25 EXO84 FIN1 FIR1 GIP4 HCM1 INP52
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Topics Genes linked to topics (#31 - 40 )
IPL1 IQG1 IRC8 KAR3 KKQ8 LRE1 LTE1 MCM3 MPC54 MPS2
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Topics Genes linked to topics (#41 - 50 )
MSA1 MSA2 MSB1 MSE1 NBP1 NDD1 ORC2 ORC6 PDS1 PKC1
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Topics Genes linked to topics (#51 - 60 )
PLM2 PMS1 RAD9 RGA2 SAK1 SIC1 SLD2 SLI15 SMC4 SRS2
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Topics Genes linked to topics (#61 - 70 )
STB1 STE20 SWI5 VNX1 WHI5 YEN1 YGR035C YML119W YOX1 ZRG8
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