Zemp I and Kutay U (2007) Nuclear export and cytoplasmic maturation of ribosomal subunits. FEBS Lett 581(15):2783-93
Abstract: Based on the characterization of ribosome precursor particles and associated trans-acting factors, a biogenesis pathway for the 40S and 60S subunits has emerged. After nuclear synthesis and assembly steps, pre-ribosomal subunits are exported through the nuclear pore complex in a Crm1- and RanGTP-dependent manner. Subsequent cytoplasmic biogenesis steps of pre-60S particles include the facilitated release of several non-ribosomal proteins, yielding fully functional 60S subunits. Cytoplasmic maturation of 40S subunit precursors includes rRNA dimethylation and pre-rRNA cleavage, allowing 40S subunits to achieve translation competence. We review current knowledge of nuclear export and cytoplasmic maturation of ribosomal subunits.
Type: Journal Article | Research Support, Non-U.S. Gov't | Review
PubMed ID: 17509569
Topics addressed in this paper
Number of different genes curated to this paper: 66
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