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Rodriguez-Colman MJ, et al.  (2010) The forkhead transcription factor hcm1 promotes mitochondrial biogenesis and stress resistance in yeast. J Biol Chem 285(47):37092-101

Abstract: In S. cerevisiae, the forkhead transcription factor Hcm1 is involved in chromosome segregation, spindle pole dynamics and budding. We found that Hcm1 interacts with the histone deacetylase Sir2 and shifts from cytoplasm to the nucleus in G1/S phase or in response to oxidative stress stimuli. The nuclear localization of Hcm1 depends on the activity of Sir2 as revealed by activators and inhibitors of the sirtuins and the delta sir2 mutant. Hcm1-overexpressing cells display more mitochondria that can be attributed to increased amounts of Abf2, a protein involved in mitochondrial biogenesis. These cells also show higher rates of oxygen consumption and improved resistance to oxidative stress that would be explained by increased catalase and Sod2 activities, and molecular chaperones such as Hsp26, Hsp30 and members of Hsp70 family. Microarray analyses also reveal increased expression of genes involved in mitochondrial energy pathways and those allowing the transition from exponential to stationary phase. Taken together these results describe a new and relevant role of Hcm1 for mitochondrial functions suggesting that this transcription factor would participate in the adaptation of cells from fermentative to respiratory metabolism.

Status: Published Type: Journal Article PubMed ID: 20847055

Topics addressed in this paper

Number of different genes curated to this paper: 52

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ABF2 ACH1 ACN9 ADR1 AIM34 ATP5 BNA1 BNA2 BNA4 BNA5
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Topics Genes linked to topics (#11 - 20 )
CAT5 FHL1 FKH1 FKH2 GAC1 GAD1 GAP1 GDH2 GRX2 GRX5
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Topics Genes linked to topics (#21 - 30 )
HCM1 HSF1 HSP26 HSP30 ICY1 ICY2 ISF1 ISU2 KGD1 LPD1
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Topics Genes linked to topics (#31 - 40 )
LSC2 MCR1 MSN4 MXR1 PIC2 POR1 POR2 PPA2 PTC7 PUT1
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Topics Genes linked to topics (#41 - 50 )
QCR10 SIR2 SKN7 SOD2 SPG5 SPI1 SSA4 SSB1 UGA1 UGA2
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Topics Genes linked to topics (#51 - 52 )
YAP1 YGP1
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