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Matsufuji Y, et al.  (2010) Transcription factor Stb5p is essential for acetaldehyde tolerance in Saccharomyces cerevisiae. J Basic Microbiol 50(5):494-8

Abstract: Transcription factor Stb5p, previously known as one of the multidrug resistance gene regulators in Saccharomyces cerevisiae, was shown here to play an essential role in acetaldehyde tolerance. A mutant strain, Deltastb5 exhibited increased acetaldehyde sensitivity, and failed to induce genes such as GND1, TKL1 and TAL1 involved in the pentose phosphate pathway (PPP) upon acetaldehyde stress. Using this strain it was revealed that Stb5p acts as a repressor for PGI1 encoding glucose-6-phosphate isomerase under acetaldehyde stress. In reverse, over-expression of Stb5p reinforced acetaldehyde tolerance to the yeast. Furthermore, various deletion mutants of the genes involved in glycolysis showed increased acetaldehyde tolerance compared to the wild-type strain. From these results, it was suggested that Stb5p participates in acetaldehyde tolerance by regulating expression of the PPP genes and PGI1, and that down-regulation of glycolytic pathway may lead to vitalization of PPP and to increased acetaldehyde tolerance. ((c) 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim).

Status: Published Type: Journal Article PubMed ID: 20806246

Topics addressed in this paper

Number of different genes curated to this paper: 36

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Topics Genes linked to topics (#1 - 10 )
ENO1 FBP1 GLK1 GND1 GPD1 GUT1 GUT2 HSP26 HXK1 HXK2
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Topics Genes linked to topics (#11 - 20 )
LAT1 PDA1 PDB1 PDC1 PDC5 PDC6 PDR1 PDR16 PDR3 PDR5
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Topics Genes linked to topics (#21 - 30 )
PDX1 PFK1 PFK2 PFK26 PFK27 PGI1 RHR2 SNQ2 STB5 TAL1
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Topics Genes linked to topics (#31 - 36 )
TDH1 TDH2 TDH3 TKL1 TPI1 TYE7
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