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Ferreira-Cerca S, et al.  (2007) Analysis of the in vivo assembly pathway of eukaryotic 40S ribosomal proteins. Mol Cell 28(3):446-57

Abstract: In eukaryotes, in vivo formation of the two ribosomal subunits from four ribosomal RNAs (rRNAs) and approximately 80 ribosomal proteins (r-proteins) involves more than 150 nonribosomal proteins and around 100 small noncoding RNAs. It is temporally and spatially organized within different cellular compartments: the nucleolus, the nucleoplasm, and the cytoplasm. Here, we present a way to analyze how eukaryotic r-proteins of the small ribosomal subunit (SSU) assemble in vivo with rRNA. Our results show that key aspects of the assembly of eukaryotic r-proteins into distinct structural parts of the SSU are similar to the in vitro assembly pathway of their prokaryotic counterparts. We observe that the establishment of a stable assembly intermediate of the eukaryotic SSU body, but not of the SSU head, is closely linked to early rRNA processing events. The formation of assembly intermediates of the head controls efficient nuclear export of the SSU and cytoplasmic pre-rRNA maturation steps.

Status: Published Type: Journal Article PubMed ID: 17996708

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Topics Genes linked to topics (#1 - 10 )
CRM1 NOC4 RDN18-1 RDN18-2 RDN37-1 RDN37-2 RPS0A RPS0B RPS10A RPS11A
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Topics Genes linked to topics (#11 - 20 )
RPS11B RPS13 RPS14A RPS14B RPS15 RPS16A RPS16B RPS17A RPS19A RPS1A
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Topics Genes linked to topics (#21 - 30 )
RPS2 RPS20 RPS24A RPS26A RPS27B RPS28B RPS29A RPS29B RPS3 RPS31
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Topics Genes linked to topics (#31 - 34 )
RPS5 RPS6A RPS9A RPS9B
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