Mizushima N (2007) Autophagy: process and function. Genes Dev 21(22):2861-73
Abstract: Autophagy is an intracellular degradation system that delivers cytoplasmic constituents to the lysosome. Despite its simplicity, recent progress has demonstrated that autophagy plays a wide variety of physiological and pathophysiological roles, which are sometimes complex. Autophagy consists of several sequential steps--sequestration, transport to lysosomes, degradation, and utilization of degradation products--and each step may exert different function. In this review, the process of autophagy is summarized, and the role of autophagy is discussed in a process-based manner.
|Status: Published||Type: Journal Article | Research Support, Non-U.S. Gov't | Review||PubMed ID: 18006683|
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