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Karanasios E and Simos G  (2010) Building arks for tRNA: structure and function of the Arc1p family of non-catalytic tRNA-binding proteins. FEBS Lett 584(18):3842-9

Abstract: Following the intricate architecture of the eukaryotic cell, protein synthesis involves formation of many macromolecular assemblies, some of which are composed by tRNA-aminoacylation enzymes. Protein-protein and protein-tRNA interactions in these complexes can be facilitated by non-catalytic tRNA-binding proteins. This review focuses on the dissection of the molecular, structural and functional properties of a particular family of such proteins: yeast Arc1p and its homologues in prokaryotes and higher eukaryotes. They represent paradigms of the strategies employed for the organization of sophisticated and dynamic nanostructures supporting spatio-temporal cellular organization.CI - Copyright (c) 2010. Published by Elsevier B.V.

Status: Published Type: Journal Article PubMed ID: 20728442

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