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Tseng CK and Cheng SC  (2008) Both catalytic steps of nuclear pre-mRNA splicing are reversible. Science 320(5884):1782-4

Abstract: Nuclear pre-messenger RNA (pre-mRNA) splicing is an essential processing step for the production of mature mRNAs from most eukaryotic genes. Splicing is catalyzed by a large ribonucleoprotein complex, the spliceosome, which is composed of five small nuclear RNAs and more than 100 protein factors. Despite the complexity of the spliceosome, the chemistry of the splicing reaction is simple, consisting of two consecutive transesterification reactions. The presence of introns in spliceosomal RNAs of certain fungi has suggested that splicing may be reversible; however, this has never been demonstrated experimentally. By using affinity-purified spliceosomes, we have shown that both catalytic steps of splicing can be efficiently reversed under appropriate conditions. These results provide considerable insight into the catalytic flexibility of the spliceosome.

Status: Published Type: Journal Article | Research Support, Non-U.S. Gov't PubMed ID: 18583613

Topics addressed in this paper

Number of different genes curated to this paper: 42

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BRR1 CBC2 CEF1 CLF1 CWC2 CWC22 ECM2 ISY1 LSM8 LSR1
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NTC20 NTR2 PRP16 PRP19 PRP22 PRP28 PRP43 PRP45 PRP46 PRP5
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SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX3 SNP1 SNR14 SNR7-L
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Topics Genes linked to topics (#31 - 40 )
SNR7-S SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP2 SPP382 SUB2
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