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Ottosson LG, et al.  (2010) Sulfate Assimilation Mediates Tellurite Reduction and Toxicity in Saccharomyces cerevisiae. Eukaryot Cell 9(10):1635-1647

Abstract: Despite a century of research and increasing environmental and human health concerns, the mechanistic basis for the toxicity and intracellular accumulation of derivates of the metalloid tellurium, in particular the oxyanion tellurite, remains unsolved. Here, we provide an unbiased view of mechanisms of tellurium metabolism in the yeast Saccharomyces cerevisiae by measuring deviations in tellurium tolerance and accumulation of a complete collection of gene knockouts. Reduction of tellurite and concomitant intracellular accumulation as metallic tellurium strongly correlated with loss of cellular fitness, demonstrating that tellurite reduction and toxicity are causally linked. The sulfate assimilation pathway upstream of Met17 and in particular the sulfite reductase and its cofactor siroheme were shown to be central to tellurite toxicity and its reduction to elemental tellurium. Gene knockouts with a deviation in tellurite tolerance also showed a similar deviation in the tolerance to both selenite and, interestingly, selenomethionine. This suggests that the bioassimilation of selenium and tellurium into seleno- and telluromethionine via the sulfate assimilation pathway, with potential further incorporation into proteins, is an important cause of tellurite and selenite toxicity in yeast. The here reported results represent a robust base from which to attack the mechanistic details of this molecular enigma.

Status: Published Type: Journal Article PubMed ID: 20675578

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MAC1 MAM33 MCK1 MDM10 MDM12 MDM31 MDM34 MDM35 MET1 MET10
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OCA4 OPI11 OPI8 OPT1 OST4 PAL1 PAP2 PBS2 PDE2 PHO80
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PIH1 PKR1 PMA2 PRS5 PSY1 PUS4 QCR9 RAD57 RCF2 RCY1
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RTG2 RTN1 RTT10 RTT101 RTT103 RTT109 RVS161 SAC3 SAM1 SAM2
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