Ferenz NP, et al. (2010) Mitotic functions of kinesin-5. Semin Cell Dev Biol 21(3):255-9
Abstract: In all eukaryotic cells, molecular motor proteins play essential roles in spindle assembly and function. The homotetrameric kinesin-5 motors in particular generate outward forces that establish and maintain spindle bipolarity and contribute to microtubule flux. Cell-cycle dependent phosphorylation of kinesin-5 motors regulates their localization to the mitotic spindle. Analysis of live cells further shows that kinesin-5 motors are highly dynamic in the spindle. Understanding the interactions of kinesin-5 motors with microtubules and other spindle proteins is likely to broaden the documented roles of kinesin-5 motors during cell division.CI - Copyright 2010 Elsevier Ltd. All rights reserved.
|Status: Published||Type: Journal Article | Review||PubMed ID: 20109572|
Topics addressed in this paper
Number of different genes curated to this paper: 3
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