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Selth LA, et al.  (2009) An rtt109-independent role for vps75 in transcription-associated nucleosome dynamics. Mol Cell Biol 29(15):4220-34

Abstract: The histone chaperone Vps75 forms a complex with, and stimulates the activity of, the histone acetyltransferase Rtt109. However, Vps75 can also be isolated on its own and might therefore possess Rtt109-independent functions. Analysis of epistatic miniarray profiles showed that VPS75 genetically interacts with factors involved in transcription regulation whereas RTT109 clusters with genes linked to DNA replication/repair. Additional genetic and biochemical experiments revealed a close relationship between Vps75 and RNA polymerase II. Furthermore, Vps75 is recruited to activated genes in an Rtt109-independent manner, and its genome-wide association with genes correlates with transcription rate. Expression microarray analysis identified a number of genes whose normal expression depends on VPS75. Interestingly, histone H2B dynamics at some of these genes are consistent with a role for Vps75 in histone H2A/H2B eviction/deposition during transcription. Indeed, reconstitution of nucleosome disassembly using the ATP-dependent chromatin remodeler Rsc and Vps75 revealed that these proteins can cooperate to remove H2A/H2B dimers from nucleosomes. These results indicate a role for Vps75 in nucleosome dynamics during transcription, and importantly, this function appears to be largely independent of Rtt109.

Status: Published Type: Journal Article | Research Support, Non-U.S. Gov't PubMed ID: 19470761

Topics addressed in this paper

Number of different genes curated to this paper: 70

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
AHC1 AQR1 ARP8 BNA2 BRE5 BSC1 CMK2 COS8 CSE2 CUR1
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Topics Genes linked to topics (#11 - 20 )
DEP1 DIA1 DST1 EAF5 EAF7 ELP3 ELP4 ELP6 FKH1 FKH2
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Topics Genes linked to topics (#21 - 30 )
FMP48 HAA1 HFI1 HHT1 HHT2 HMS1 HOS4 HSP30 HTB1 HTB2
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Topics Genes linked to topics (#31 - 40 )
IKI1 IOC4 ISF1 IWR1 MCH5 MED1 MED4 MET2 MGA1 NGG1
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Topics Genes linked to topics (#41 - 50 )
NUT1 PHM8 PRM2 PRM7 RGS2 RPD3 RPO21 RSC1 RTT109 RXT2
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Topics Genes linked to topics (#51 - 60 )
SDS3 SET3 SGF11 SGF73 SPI1 STP4 TDA6 TMA10 TPO2 UBP3
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Topics Genes linked to topics (#61 - 70 )
VPS75 YAF9 YDL038C YER130C YHR177W YJR079W YLR297W YNG2 YOL014W YPL014W
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