Molina M, et al. (2010) Fine regulation of Saccharomyces cerevisiae MAPK pathways by post-translational modifications. Yeast 27(8):503-11
Abstract: Saccharomyces cerevisiae has been widely used as a model eukaryotic organism to elucidate the molecular mechanisms that operate upon activation of signalling pathways. For over two decades, many clues to the regulation of mitogen-activated protein kinase (MAPK) pathways have derived from basic research in yeast. Here we review aspects of MAPK pathway fine-tuning, such as the functional implication of feedback loops or regulatory inputs from other pathways, mediated by post-transcriptional modifications on their components. The impact of recent phosphoproteomic approaches in this particular field is also discussed. Copyright (c) 2010 John Wiley & Sons, Ltd.
|Status: Published||Type: Journal Article||PubMed ID: 20641029|
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