SGD Paper Help


Page Contents:
Suzuki K, et al.  (2010) Selective transport of alpha-mannosidase by autophagic pathways: identification of a novel receptor, Atg34p. J Biol Chem 285(39):30019-25

Abstract: In Saccharomyces cerevisiae, aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) are known cargoes of selective autophagy. Atg19p has been identified as an Ape1p receptor and targets Ape1p to the pre-autophagosomal structure (PAS). Under nutrient-rich conditions, transport of Ams1p to the vacuole largely depends on Atg19p. Here, we show that Atg34p (Yol083wp), a homolog of Atg19p, is a receptor for Ams1p transport during autophagy. Atg34p interacts with Ams1p, Atg11p, and Atg8p using distinct domains. Ams1p forms a homooligomer after synthesis and binds to the Ams1-binding domain of Atg34p; this binding is important for the formation of a higher-order complex named the Ams1 complex. In the absence of the interaction of Atg34p with Atg8p, the Ams1 complex is targeted to the PAS but fails to transit to the vacuole, indicating that the interaction of Atg34p with Atg8p is crucial for the Ams1 complex to be enclosed by autophagosomes. Atg34p and Atg19p have similar domain structures and are important for Ams1p transport during autophagy.

Status: Published Type: Journal Article PubMed ID: 20639194

Topics addressed in this paper

Number of different genes curated to this paper: 8

  • To find other papers on a gene and topic, click on the colored ball in the appropriate box.
  • displays other papers with information about that topic for that gene.
  • displays other papers in SGD that are associated with that topic.
    The topic is addressed in these papers but does not describe a specific gene or chromosomal feature.
  • To go to the Locus page for a gene, click on the gene name.
Topics Genes linked to topics
AME1 AMS1 APE1 ATG1 ATG11 ATG19 ATG34 ATG8
Additional Literature blue ball blue ball blue ball blue ball blue ball
Alias blue ball
Cellular Location blue ball blue ball
Function/Process blue ball blue ball
Genetic Interactions blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball
Protein Processing/Modification/Regulation blue ball blue ball
Protein Sequence Features blue ball
Protein-protein Interactions blue ball
Regulation of blue ball
Strains/Constructs blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Substrates/Ligands/Cofactors blue ball

Author Searches

To find contact information or other publications by the authors of this paper, follow these three steps:
  1. (1) Choose an author,
  2. (2) Choose a search parameter,
  3. (3) Click to implement
Page Contents: