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Bonnet J, et al.  (2010) The structural plasticity of SCA7 domains defines their differential nucleosome-binding properties. EMBO Rep 11(8):612-8

Abstract: SAGA (Spt-Ada-Gcn5 acetyltransferase), a coactivator complex involved in chromatin remodelling, harbours both histone acetylation and deubiquitination activities. ATXN7/Sgf73 and ATXN7L3, two subunits of the SAGA deubiquitination module, contain an SCA7 domain characterized by an atypical zinc-finger. We show that the yeast Sgf73-SCA7 domain is not required to recruit Sgf73 into SAGA. Instead, it binds to nucleosomes, a property that is conserved in the human ATXN7-SCA7 domain but is lost in the ATXN7L3 domain. The solution structures of the SCA7 domain of both ATXN7 and ATXN7L3 reveal a new, common zinc-finger motif at the heart of two distinct folds, providing a molecular basis for the observed functional differences.

Status: Published Type: Journal Article PubMed ID: 20634802

Topics addressed in this paper

Number of different genes curated to this paper: 22

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Topics Genes linked to topics (#1 - 10 )
ADA2 CHD1 GCN5 HFI1 HTB1 HTB2 NGG1 SGF11 SGF29 SGF73
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Fungal Related Genes/Proteins blue ball
Mutants/Phenotypes blue ball
Non-Fungal Related Genes/Proteins blue ball blue ball
Primary Literature blue ball blue ball
Protein Processing/Modification/Regulation blue ball blue ball
Protein Sequence Features blue ball blue ball
Protein-Nucleic Acid Interactions blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Strains/Constructs blue ball

Topics Genes linked to topics (#11 - 20 )
SPT20 SPT3 SPT7 SPT8 SUS1 TAF10 TAF12 TAF5 TAF6 TAF9
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#21 - 22 )
TRA1 UBP8
Additional Literature blue ball blue ball
Mutants/Phenotypes blue ball
Protein-protein Interactions blue ball blue ball
Strains/Constructs blue ball

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