Zickermann V, et al. (2010) Small single transmembrane domain (STMD) proteins organize the hydrophobic subunits of large membrane protein complexes. FEBS Lett 584(12):2516-25
Abstract: The large membrane protein complexes of mitochondrial oxidative phosphorylation are composed of central subunits that are essential for their bioenergetic core function and accessory subunits that may assist in regulation, assembly or stabilization. Although sequence conservation is low, a significant proportion of the accessory subunits is characterized by a common single transmembrane (STMD) topology. The STMD signature is also found in subunits of other membrane protein complexes. We hypothesize that the general function of STMD subunits is to organize the hydrophobic subunits of large membrane protein complexes in specialized environments like the inner mitochondrial membrane.CI - Copyright 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
| Status: Published | Type: Comparative Study | Journal Article | Research Support, Non-U.S. Gov't | Review | PubMed ID: 20398659 |
Topics addressed in this paper
Number of different genes curated to this paper: 39
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| Topics | Genes linked to topics (#1 - 10 ) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| ATP1 | ATP14 | ATP15 | ATP16 | ATP17 | ATP18 | ATP19 | ATP2 | ATP20 | ATP3 | |
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| Topics | Genes linked to topics (#11 - 20 ) | |||||||||
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| ATP4 | ATP5 | ATP6 | ATP7 | ATP8 | COB | COR1 | COX1 | COX12 | COX13 | |
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| Topics | Genes linked to topics (#21 - 30 ) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| COX2 | COX3 | COX4 | COX5A | COX5B | COX6 | COX7 | COX8 | COX9 | CYT1 | |
| Reviews | | | | | | | | | | |
- To find other papers on a gene and topic, click on the colored ball in the appropriate box.
- displays other papers with information about that topic for that gene.
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The topic is addressed in these papers but does not describe a specific gene or chromosomal feature.
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