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Zickermann V, et al.  (2010) Small single transmembrane domain (STMD) proteins organize the hydrophobic subunits of large membrane protein complexes. FEBS Lett 584(12):2516-25

Abstract: The large membrane protein complexes of mitochondrial oxidative phosphorylation are composed of central subunits that are essential for their bioenergetic core function and accessory subunits that may assist in regulation, assembly or stabilization. Although sequence conservation is low, a significant proportion of the accessory subunits is characterized by a common single transmembrane (STMD) topology. The STMD signature is also found in subunits of other membrane protein complexes. We hypothesize that the general function of STMD subunits is to organize the hydrophobic subunits of large membrane protein complexes in specialized environments like the inner mitochondrial membrane.CI - Copyright 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Status: Published Type: Comparative Study | Journal Article | Research Support, Non-U.S. Gov't | Review PubMed ID: 20398659

Topics addressed in this paper

Number of different genes curated to this paper: 39

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Topics Genes linked to topics (#1 - 10 )
ATP1 ATP14 ATP15 ATP16 ATP17 ATP18 ATP19 ATP2 ATP20 ATP3
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Topics Genes linked to topics (#11 - 20 )
ATP4 ATP5 ATP6 ATP7 ATP8 COB COR1 COX1 COX12 COX13
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Topics Genes linked to topics (#21 - 30 )
COX2 COX3 COX4 COX5A COX5B COX6 COX7 COX8 COX9 CYT1
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Topics Genes linked to topics (#31 - 39 )
OLI1 QCR10 QCR2 QCR6 QCR7 QCR8 QCR9 RIP1 TIM11
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