Oeffinger M (2010) Joining the interface: a site for Nmd3 association on 60S ribosome subunits. J Cell Biol 189(7):1071-3
Abstract: The adaptor protein Nmd3 is required for Crm1-dependent export of large ribosomal subunits from the nucleus. In this issue, Sengupta et al. (2010. J. Cell Biol. doi:10.1083/jcb.201001124) identify a binding site for yeast Nmd3 on 60S ribosomal subunits using cryoelectron microscopy and suggest a conformational model for its release in the cytoplasm. The study provides the first detailed structural description of a ribosome biogenesis factor in complex with the large subunit.
|Status: Published||Type: Journal Article | Research Support, Non-U.S. Gov't||PubMed ID: 20584913|
Topics addressed in this paper
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