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Burgess RJ, et al.  (2010) A role for Gcn5 in replication-coupled nucleosome assembly. Mol Cell 37(4):469-80

Abstract: Acetylation of lysine residues at the H3 N terminus is proposed to function in replication-coupled (RC) nucleosome assembly, a process critical for the inheritance of epigenetic information and maintenance of genome stability. However, the role of H3 N-terminal lysine acetylation and the corresponding lysine acetyltransferase (KAT) in RC nucleosome assembly are not known. Here we show that Gcn5, a KAT that functions in transcription, works in parallel with Rtt109, the H3 lysine 56 KAT, to promote RC nucleosome assembly. Cells lacking both Gcn5 and Rtt109 are highly sensitive to DNA damaging agents. Moreover, cells lacking GCN5 or those that express N-terminal H3 mutants are compromised for deposition of new H3 onto replicating DNA and also show reduced binding of H3 to CAF-1, a histone chaperone involved in RC nucleosome assembly. These results demonstrate that Gcn5 regulates RC nucleosome assembly, in part, by promoting H3 association with CAF-1 via H3 acetylation.

Status: Published Type: Journal Article | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't PubMed ID: 20188666

Topics addressed in this paper

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Topics Genes linked to topics (#1 - 10 )
ADA2 AHC1 AHC2 ASF1 CAC2 CDC7 CHD1 ELP3 GCN5 HFI1
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Topics Genes linked to topics (#11 - 20 )
MEC1 NGG1 POL1 RAD53 RLF2 RTG2 RTT106 RTT109 SGF11 SGF29
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Topics Genes linked to topics (#21 - 27 )
SGF73 SPT20 SPT3 SPT7 SPT8 UBP8 VPS75
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