SGD Paper Help


Page Contents:
Zhou BO, et al.  (2010) SWR1 complex poises heterochromatin boundaries for antisilencing activity propagation. Mol Cell Biol 30(10):2391-400

Abstract: In eukaryotes, chromosomal processes are usually modulated through chromatin-modifying complexes that are dynamically targeted to specific regions of chromatin. In this study, we show that the chromatin-remodeling complex SWR1 (SWR1-C) uses a distinct strategy to regulate heterochromatin spreading. Swr1 binds in a stable manner near heterochromatin to prepare specific chromosomal regions for H2A.Z deposition, which can be triggered by NuA4-mediated acetylation of histone H4. We also demonstrate through experiments with Swc4, a module shared by NuA4 and SWR1-C, that the coupled actions of NuA4 and SWR1-C lead to the efficient incorporation of H2A.Z into chromatin and thereby synergize heterochromatin boundary activity. Our results support a model where SWR1-C resides at the heterochromatin boundary to maintain and amplify antisilencing activity of histone H4 acetylation through incorporating H2A.Z into chromatin.

Status: Published Type: Journal Article | Research Support, Non-U.S. Gov't PubMed ID: 20308321

Topics addressed in this paper

Number of different genes curated to this paper: 45

Jump to Summary Chart for:
  • To find other papers on a gene and topic, click on the colored ball in the appropriate box.
  • displays other papers with information about that topic for that gene.
  • displays other papers in SGD that are associated with that topic.
    The topic is addressed in these papers but does not describe a specific gene or chromosomal feature.
  • To go to the Locus page for a gene, click on the gene name.
Topics Genes linked to topics (#1 - 10 )
ACT1 ADH7 ARP4 ARP6 EAF1 EAF3 EAF5 EAF6 EAF7 EPL1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Function/Process blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Genetic Interactions blue ball
Mutants/Phenotypes blue ball
Primary Literature blue ball
Regulation of blue ball
RNA Levels and Processing blue ball
Strains/Constructs blue ball

Topics Genes linked to topics (#11 - 20 )
ESA1 GIT1 GTT1 HHF1 HHF2 HML HMR HTZ1 NOP1 OCA4
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball
Cellular Location blue ball
Function/Process blue ball
Mutants/Phenotypes blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball blue ball
Protein Processing/Modification/Regulation blue ball blue ball blue ball
Protein-Nucleic Acid Interactions blue ball blue ball blue ball blue ball blue ball
Protein-protein Interactions blue ball
Regulation of blue ball blue ball blue ball blue ball
Regulatory Role blue ball
RNA Levels and Processing blue ball blue ball blue ball
Strains/Constructs blue ball blue ball blue ball blue ball
Substrates/Ligands/Cofactors blue ball
Techniques and Reagents blue ball blue ball

Topics Genes linked to topics (#21 - 30 )
PAU15 PAU6 RDS1 RVB1 RVB2 SIR2 SIR3 SWC3 SWC4 SWC5
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cellular Location blue ball
Function/Process blue ball blue ball blue ball blue ball blue ball
Genetic Interactions blue ball
Mutants/Phenotypes blue ball blue ball
Primary Literature blue ball blue ball
Protein Sequence Features blue ball
Protein-Nucleic Acid Interactions blue ball blue ball blue ball
Protein-protein Interactions blue ball
Regulation of blue ball blue ball blue ball
Regulatory Role blue ball
RNA Levels and Processing blue ball blue ball blue ball
Strains/Constructs blue ball blue ball
Substrates/Ligands/Cofactors blue ball blue ball
Jump to Summary Chart for:
  • To find other papers on a gene and topic, click on the colored ball in the appropriate box.
  • displays other papers with information about that topic for that gene.
  • displays other papers in SGD that are associated with that topic.
    The topic is addressed in these papers but does not describe a specific gene or chromosomal feature.
  • To go to the Locus page for a gene, click on the gene name.

Topics Genes linked to topics (#31 - 40 )
SWC7 SWR1 TRA1 VPS71 VPS72 YAF9 YCR099C YCR100C YCR101C YCR102C
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Function/Process blue ball blue ball blue ball blue ball blue ball blue ball
Genetic Interactions blue ball
Mutants/Phenotypes blue ball
Primary Literature blue ball
Protein-Nucleic Acid Interactions blue ball
Protein-protein Interactions blue ball
Regulation of blue ball blue ball blue ball blue ball
Regulatory Role blue ball
RNA Levels and Processing blue ball blue ball blue ball blue ball
Strains/Constructs blue ball
Substrates/Ligands/Cofactors blue ball

Topics Genes linked to topics (#41 - 45 )
YIR042C YIR043C YIR044C YNG2 YPS6
Additional Literature blue ball blue ball blue ball blue ball blue ball
Function/Process blue ball
Regulation of blue ball blue ball blue ball blue ball
RNA Levels and Processing blue ball blue ball blue ball blue ball

Author Searches

To find contact information or other publications by the authors of this paper, follow these three steps:
  1. (1) Choose an author,
  2. (2) Choose a search parameter,
  3. (3) Click to implement
Page Contents: