SGD Paper Help


Page Contents:
Breitkreutz A, et al.  (2010) A global protein kinase and phosphatase interaction network in yeast. Science 328(5981):1043-6

Abstract: The interactions of protein kinases and phosphatases with their regulatory subunits and substrates underpin cellular regulation. We identified a kinase and phosphatase interaction (KPI) network of 1844 interactions in budding yeast by mass spectrometric analysis of protein complexes. The KPI network contained many dense local regions of interactions that suggested new functions. Notably, the cell cycle phosphatase Cdc14 associated with multiple kinases that revealed roles for Cdc14 in mitogen-activated protein kinase signaling, the DNA damage response, and metabolism, whereas interactions of the target of rapamycin complex 1 (TORC1) uncovered new effector kinases in nitrogen and carbon metabolism. An extensive backbone of kinase-kinase interactions cross-connects the proteome and may serve to coordinate diverse cellular responses.

Status: Published Type: Journal Article PubMed ID: 20489023

Topics addressed in this paper

Number of different genes curated to this paper: 46

Jump to Summary Chart for:
  • To find other papers on a gene and topic, click on the colored ball in the appropriate box.
  • displays other papers with information about that topic for that gene.
  • displays other papers in SGD that are associated with that topic.
    The topic is addressed in these papers but does not describe a specific gene or chromosomal feature.
  • To go to the Locus page for a gene, click on the gene name.
Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ACE2 AVO1 AVO2 BCK1 BIT61 BOI1 CBK1 CDC14 CDC15 CDC28
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Computational analysis yg ball
Function/Process blue ball
Genetic Interactions blue ball blue ball
Large-scale protein interaction yg ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball
Omics yg ball
Other genomic analysis yg ball
Other large-scale proteomic analysis yg ball
Primary Literature blue ball blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Strains/Constructs blue ball blue ball blue ball blue ball
Substrates/Ligands/Cofactors blue ball

Topics Genes linked to topics (#11 - 20 )
CHK1 CLB2 DUN1 FMP48 FRK1 FUS3 GCN2 GDH2 GLN3 IME2
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cellular Location blue ball
Function/Process blue ball
Genomic expression study blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball
Primary Literature blue ball blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Regulation of blue ball
Regulatory Role blue ball
Strains/Constructs blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#21 - 30 )
KDX1 KOG1 KSP1 LST8 MIH1 MPS1 NET1 NNK1 NPR1 PBS2
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Function/Process blue ball blue ball blue ball blue ball
Genetic Interactions blue ball
Genomic expression study blue ball
Mutants/Phenotypes blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Regulatory Role blue ball
Strains/Constructs blue ball blue ball blue ball
Jump to Summary Chart for:
  • To find other papers on a gene and topic, click on the colored ball in the appropriate box.
  • displays other papers with information about that topic for that gene.
  • displays other papers in SGD that are associated with that topic.
    The topic is addressed in these papers but does not describe a specific gene or chromosomal feature.
  • To go to the Locus page for a gene, click on the gene name.

Topics Genes linked to topics (#31 - 40 )
RIO2 RTK1 SAK1 SIR2 SKY1 SLT2 SNF1 STE7 SWE1 TCO89
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Function/Process blue ball blue ball
Genetic Interactions blue ball
Mutants/Phenotypes blue ball blue ball blue ball
Primary Literature blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Strains/Constructs blue ball blue ball blue ball

Topics Genes linked to topics (#41 - 46 )
TOR1 TOR2 TPK2 TRA1 TSC11 URE2
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball
Function/Process blue ball blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball blue ball

Author Searches

To find contact information or other publications by the authors of this paper, follow these three steps:
  1. (1) Choose an author,
  2. (2) Choose a search parameter,
  3. (3) Click to implement
Page Contents: