Zhu Y, et al. (2010) [Effect of epigallocatechin-3-gallate on the activity of alpha-glucosidase in vitro] Wei Sheng Yan Jiu 39(2):168-71, 176
Abstract: OBJECTIVE: To investigate the effect of epigallocatechin-3-gallate (EGCG) on the activity of alpha-glucosidase derived from bakers' yeast and small intestinal mucosa of Wistar rats, in order to establish an evaluation system for the activity of alpha-glucosidase inhibitor. METHODS: alpha-glucosidase was prepared from the bakers' yeast and the small intestinal mucosa of Wistar rats. The inhibitory activity of EGCG on alpha-glucosidase was based on the concentration of glucose in the reaction system. RESULTS: EGCG was shown to be an alpha-glucosidase inhibitor. IC50 was 0.150 mg/ml and 0.837 mg/ml for alpha-glucosidase derived from bakers' yeast and small intestinal mucosa respectively. CONCLUSION: The establishment of an in vitro evaluation system for AGI activity is conductive for screening alpha-glucosidase inhibitory substance. The AGI activity of EGCG is strong in vitro.
|Status: Published||Type: English Abstract | Journal Article||PubMed ID: 20459029|
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