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Floer M, et al.  (2010) A RSC/nucleosome complex determines chromatin architecture and facilitates activator binding. Cell 141(3):407-18

Abstract: How is chromatin architecture established and what role does it play in transcription? We show that the yeast regulatory locus UASg bears, in addition to binding sites for the activator Gal4, sites bound by the RSC complex. RSC positions a nucleosome, evidently partially unwound, in a structure that facilitates Gal4 binding to its sites. The complex comprises a barrier that imposes characteristic features of chromatin architecture. In the absence of RSC, ordinary nucleosomes encroach over the UASg and compete with Gal4 for binding. Taken with our previous work, the results show that both prior to and following induction, specific DNA-binding proteins are the predominant determinants of chromatin architecture at the GAL1/10 genes. RSC/nucleosome complexes are also found scattered around the yeast genome. Higher eukaryotic RSC lacks the specific DNA-binding determinants found on yeast RSC, and evidently Gal4 works in those organisms despite whatever obstacle broadly positioned nucleosomes present.CI - 2010 Elsevier Inc. All rights reserved.

Status: Published Type: Journal Article | Research Support, N.I.H., Extramural PubMed ID: 20434983

Topics addressed in this paper

Number of different genes curated to this paper: 20

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Topics Genes linked to topics (#1 - 10 )
ARP7 ARP9 GAL1 GAL10 HTL1 LDB7 NPL6 RSC1 RSC2 RSC3
Additional Literature blue ball blue ball
Cellular Location blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cross-species Expression blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Protein-Nucleic Acid Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Regulation of blue ball blue ball
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Topics Genes linked to topics (#11 - 20 )
RSC30 RSC4 RSC58 RSC6 RSC8 RSC9 RTT102 SFH1 STH1 TAF14
Cellular Location blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cross-species Expression blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Function/Process blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball
Primary Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein-Nucleic Acid Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Regulatory Role blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

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