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Gardarin A, et al.  (2010) Endoplasmic reticulum is a major target of cadmium toxicity in yeast. Mol Microbiol 76(4):1034-48

Abstract: SUMMARY Cadmium (Cd(2+)) is a very toxic metal which causes DNA damage, oxidative stress and apoptosis. Despite many studies, the cellular and molecular mechanisms underlying its high toxicity are not clearly understood. We show here that very low doses of Cd(2+) cause ER stress in Saccharomyces cerevisiae as evidenced by the induction of the Unfolded Protein Response (UPR) and the splicing of HAC1 mRNA. Furthermore, mutant strains (Deltaire1 and Deltahac1) unable to induce the UPR are hypersensitive to Cd(2+), but not to arsenite and mercury. The full functionality of the pathways involved in ER stress response is required for Cd(2+) tolerance. The data also suggest that Cd(2+)-induced ER stress and Cd(2+) toxicity are a direct consequence of Cd(2+) accumulation in the ER. Cd(2+) does not inhibit disulfide bond formation but perturbs calcium metabolism. In particular, Cd(2+) activates the calcium channel Cch1/Mid1, which also contributes to Cd(2+) entry into the cell. The results reinforce the interest of using yeast as a cellular model to study toxicity mechanisms in eukaryotic cells.

Status: Published Type: Journal Article PubMed ID: 20444096

Topics addressed in this paper

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Topics Genes linked to topics (#1 - 10 )
ALD4 ALG3 ALG9 ATG17 BCK1 CCH1 CNB1 DER1 DFR1 DID2
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Topics Genes linked to topics (#11 - 20 )
DOG1 DOG2 ERO1 ERV29 EUG1 FLC1 FPR2 FPS1 FYV8 HAC1
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Topics Genes linked to topics (#21 - 30 )
HOG1 IRE1 JEM1 KAR2 KTR7 LHS1 MCD4 MGR1 MID2 MMS21
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Topics Genes linked to topics (#31 - 40 )
MPD1 OPI8 PDI1 PDR12 PMI40 PMR1 POL3 SEC26 SEC59 SLT2
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Topics Genes linked to topics (#41 - 47 )
SSK1 SWE1 TOS3 URA1 URH1 YET2 YIP3
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