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Li M, et al.  (2010) Identifying the overlapping complexes in protein interaction networks. Int J Data Min Bioinform 4(1):91-108

Abstract: Identification of protein complexes in large interaction networks is crucial to understanding principles of cellular organisation and predict protein functions. In this paper, a new algorithm of Identifying Protein Complexes based on Maximal Clique Extension (IPC-MCE) is proposed. The maximal clique is considered as the core of the protein complex. Proteins in a complex are classed into core vertices and peripheral vertices. The relation between the core vertices and peripheral vertices is measured by the Interaction Probability. The algorithm IPC-MCE is applied to the protein interaction network of Saccharomyces cerevisiae. Many well-known protein complexes are detected.

Status: Published Type: Journal Article | Research Support, Non-U.S. Gov't PubMed ID: 20376924

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ADA2 APC1 APC11 APC2 APC4 APC5 APC9 BET3 BET5 CDC16
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Computational analysis yg ball
Omics yg ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#11 - 20 )
CDC23 CDC26 CDC27 DOC1 GCN5 HFI1 NGG1 NIP1 PRT1 RPG1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#21 - 30 )
SPT20 SPT3 SPT7 SPT8 SUI1 TAF10 TAF12 TAF5 TAF6 TAF9
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#31 - 40 )
TIF34 TIF35 TIF5 TRA1 TRS120 TRS130 TRS20 TRS31 TRS33 TRS65
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

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