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Zhao J, et al.  (2010) The protein kinase Hal5p is the high-copy suppressor of lithium-sensitive mutations of genes involved in the sporulation and meiosis as well as the ergosterol biosynthesis in Saccharomyces cerevisiae. Genomics 95(5):290-8

Abstract: From a genome-scale genetic screen, we have identified 114 lithium-sensitive and 6 lithium-tolerant gene mutations in Saccharomyces cerevisiae. Twenty-five of these identified lithium-sensitive mutations are of genes previously reported to be involved in sporulation and meiosis, whereas thirty-six of them are of genes involved in the vacuolar protein sorting (VPS) pathway, mainly functioning in the membrane docking and fusion. Accordingly, the lithium-sensitive phenotypes for one third of identified VPS mutants well correlate to their intracellular lithium contents in response to lithium stress. This indicates the integrity of the VPS pathway is critic for the ion homeostasis in yeast cells. The halotolerant protein kinase Hal5p, a regulator of the potassium transporter Trk1p, is shown to be the high-copy suppressor of nearly one third of identified lithium-sensitive mutations of genes involved in the sporulation and meiosis as well as in the biosynthesis of ergosterol. These results suggest that Hal5p-mediated ion homeostasis is important for these two biological processes.CI - Copyright (c) 2010. Published by Elsevier Inc.

Status: Published Type: Journal Article PubMed ID: 20206679

Topics addressed in this paper

Number of different genes curated to this paper: 86

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ARC1 BDF1 BRO1 CHS5 CNB1 CRZ1 CSG2 DID2 DID4 DOA1
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Topics Genes linked to topics (#11 - 20 )
EAF1 ERG3 ERG4 ERG5 ERG6 FYV5 GIS4 GUP1 HAL5 HOM6
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Topics Genes linked to topics (#21 - 30 )
HUR1 IMP2' ISY1 LOA1 MCK1 MDM20 MNN10 MON2 NMD2 NRG1
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Topics Genes linked to topics (#31 - 40 )
PEP3 PEP7 PLC1 PMR1 PPZ1 PSP2 PTC1 RMD1 RPS9B RSC1
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Topics Genes linked to topics (#41 - 50 )
RSC2 RVS161 SAC7 SCP160 SNF7 SNF8 SPT10 SRN2 STP22 SUR4
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Topics Genes linked to topics (#51 - 60 )
TRK1 TRS85 TUS1 URE2 VAM3 VAM6 VAM7 VID22 VPS1 VPS16
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Topics Genes linked to topics (#61 - 70 )
VPS20 VPS25 VPS27 VPS28 VPS3 VPS33 VPS36 VPS4 VPS51 VPS52
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Topics Genes linked to topics (#71 - 80 )
VPS53 VPS55 VPS60 VPS61 VPS63 VPS65 VPS68 VPS69 VPS71 VPS72
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Topics Genes linked to topics (#81 - 86 )
VPS74 VPS75 VPS8 VPS9 YGL072C YML094C-A
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