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Chen SH, et al.  (2010) A proteome-wide analysis of kinase-substrate network in the DNA damage response. J Biol Chem 285(17):12803-12

Abstract: The DNA damage checkpoint, consisting of an evolutionarily conserved protein kinase cascade, controls the DNA damage response in eukaryotes. Knowledge of the in vivo substrates of the checkpoint kinases is essential towards understanding their functions. Here we used quantitative mass spectrometry to identify 53 new and 34 previously known targets of Mec1/Tel1, Rad53 and Dun1 in Saccharomyces cerevisiae. Analysis of Replication Protein-A (RPA) associated proteins reveals extensive physical interactions between RPA-associated proteins and Mec1/Tel1 specific substrates. Among them, multiple subunits of the chromatin remodeling complexes including ISW1, ISW2, INO80, SWR1, RSC and SWI/SNF are identified and they undergo DNA damage induced phosphorylation by Mec1 and Tel1. Taken together, this study greatly expands the existing knowledge of the targets of DNA damage checkpoint kinases and provides insights into the role of RPA-associated chromatins in mediating Mec1 and Tel1 substrate phosphorylation in vivo.

Status: Published Type: Journal Article PubMed ID: 20190278

Topics addressed in this paper

Number of different genes curated to this paper: 83

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ARP5 ARP7 ARP8 ASG1 BDF1 CBF1 CBF5 CDC73 DAD1 DAD3
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Topics Genes linked to topics (#11 - 20 )
DBF4 DNA2 DPB4 DUN1 EAF3 ECM21 GLC7 GLE1 HFI1 HPC2
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Topics Genes linked to topics (#21 - 30 )
HPR1 HSP12 HSP26 HTA1 HTA2 HTB2 IES1 IES3 IES4 INO80
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Topics Genes linked to topics (#31 - 40 )
IOC2 ISW1 ISW2 LEO1 MCD1 MEC1 MLP1 MRC1 MRP8 MSH6
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Topics Genes linked to topics (#41 - 50 )
NPL3 NUP1 NUP159 NUP60 PRP19 RAD52 RAD53 RAD9 RCO1 RFA1
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Topics Genes linked to topics (#51 - 60 )
RFA2 RFA3 RFX1 RLP7 RNR3 RPH1 RSC2 RSC30 RSC4 RSC8
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Topics Genes linked to topics (#61 - 70 )
RTT102 RTT107 SEC3 SGF73 SIN3 SLX4 SNF2 SNF5 SNF6 SPN1
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Topics Genes linked to topics (#71 - 80 )
SPT20 SPT7 STH1 SUM1 SWI3 SWR1 TAF10 TAF12 TAF14 TAF9
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Topics Genes linked to topics (#81 - 83 )
TEL1 YSH1 YTA7
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