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Ogiwara H, et al.  (2007) The INO80 chromatin remodeling complex functions in sister chromatid cohesion. Cell Cycle 6(9):1090-5

Abstract: Here we identify a defect in sister chromatid cohesion in the Saccharomyces serevisiae arp8 mutant, which impairs the chromatin remodeling activity of the INO80 complex, and we report the direct association of Ino80 with centromeres and cohesin-associated regions. In early S phase, Ino80 is recruited to replication forks along with Ctf18 and PCNA, both of which are involved in the establishment of sister chromatid cohesion. The arp8 mutation perturbs the association of Ctf18 and PCNA but not of cohesin with replication forks. We propose that the INO80 complex is required for the proper establishment of sister chromatid cohesion.

Status: Published Type: Journal Article | Research Support, Non-U.S. Gov't PubMed ID: 17471029

Topics addressed in this paper

Number of different genes curated to this paper: 12

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Topics Genes linked to topics (#1 - 10 )
ARP8 ARS607 ARS609 CBF2 CSE4 CTF18 CTF3 INO80 MCD1 MIF2
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Topics Genes linked to topics (#11 - 12 )
MTW1 NUF2
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