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Postma L, et al.  (2009) Surviving in the cold: yeast mutants with extended hibernating lifespan are oxidant sensitive. Aging (Albany NY) 1(11):957-60

Abstract: Metabolic activity generates oxidizing molecules throughout life, but it is still debated if the resulting damage of macromolecules is a causality, or consequence, of the aging process. This problem demands for studying growth- and longevity phenotypes separately. Here, we assayed a complete collection of haploid Saccharomyces cerevisiae knock-out strains for their capacity to endure long periods at low metabolic rates. Deletion of 93 genes, predominantly factors of primary metabolism, allowed yeast to survive for more than 58 months in the cold. The majority of these deletion strains were not resistant against oxidants or reductants, but many were hypersensitive. Hence, survival at low metabolic rates has limiting genetic components, and correlates with stress resistance inversely. Indeed, maintaining the energy consuming anti-oxidative machinery seems to be disadvantageous under coldroom conditions.

Status: Published Type: Journal Article PubMed ID: 20157578

Topics addressed in this paper

Number of different genes curated to this paper: 92

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ABZ2 ADR1 AIM46 ALK1 APD1 BMT2 BNA7 BUD2 CIT1 CPR8
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Large-scale phenotype analysis yg ball
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Topics Genes linked to topics (#11 - 20 )
CRH1 CUP9 DAP1 DIT1 DPB4 EAF3 ENT3 FLC1 FYV7 GLO4
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Topics Genes linked to topics (#21 - 30 )
GPA1 GTO1 HIS2 HOS4 HSP30 HXT1 IMO32 IOC2 IRC21 IRE1
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Topics Genes linked to topics (#31 - 40 )
LSC1 MBP1 MEH1 MKC7 MRP8 MRPS9 OPY1 PMP2 PNC1 PRM3
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Topics Genes linked to topics (#41 - 50 )
PTC3 PUG1 RAD16 RBG1 RCO1 RDH54 REC8 RPL22B RPL35B RPS11B
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Topics Genes linked to topics (#51 - 60 )
RUB1 RUP1 SEC28 SNC2 SPO71 TEM1 THI2 THI74 TNA1 TRX2
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Topics Genes linked to topics (#61 - 70 )
UBC4 UBR2 WTM2 YAT1 YBR137W YBR300C YCL042W YEA4 YGL042C YGL165C
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Topics Genes linked to topics (#71 - 80 )
YGR122W YGR182C YGR259C YIL100W YJL169W YJR107W YKL075C YKL151C YLH47 YLL054C
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Topics Genes linked to topics (#81 - 90 )
YLL056C YLR455W YMR075C-A YMR316C-A YNL034W YOR088W YOR093C YOR240W YPL034W YPL108W
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Topics Genes linked to topics (#91 - 92 )
YPL114W YSW1
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