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Ratnakumar S and Young ET  (2010) Snf1 dependence of peroxisomal gene expression is mediated by Adr1. J Biol Chem 285(14):10703-14

Abstract: Eukaryotes utilize fatty acids by b-oxidation, which occurs in the mitochondria and peroxisomes in higher organisms and in the peroxisomes in yeast. The AMP-activated protein kinase regulates this process in mammalian cells, and its homolog Snf1, together with the transcription factors Adr1, Oaf1 and Pip2, regulates peroxisome proliferation and b-oxidation in yeast. A constitutive allele of Adr1 (Adr1c) lacking the glucose- and Snf1-regulated phosphorylation substrate Ser230 was found to be Snf1-independent for regulation of peroxisomal genes. In addition, it could compensate for, and even suppress the requirement for Oaf1 or Pip2 for gene induction. Peroxisomal genes were found to be regulated by oleate in the presence of glucose, as long as Adr1c was expressed, suggesting that the Oaf1/Pip2 heterodimer is Snf1-independent. Consistent with this observation, Oaf1 binding to promoters in the presence of oleate was not reduced in a snf1 strain. Exploring the mechanism by which Adr1c permits Snf1-independent peroxisomal gene induction, we found that strength of promoter binding did not correlate with transcription, suggesting that stable binding is not a prerequisite for enhanced transcription. Instead, enhanced transcriptional activation, and suppression of Oaf1, Pip2 and Snf1 by Adr1c may be related to the ability of Adr1c to suppress the requirement for, and enhance the recruitment of transcriptional coactivators in a promoter- and growth-medium-dependent manner.

Status: Published Type: Journal Article PubMed ID: 20139423

Topics addressed in this paper

Number of different genes curated to this paper: 65

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Topics Genes linked to topics (#1 - 10 )
ADA2 ADH2 ADR1 ADY2 ARP7 ARP9 CSE2 CTA1 FAA2 FOX2
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Topics Genes linked to topics (#11 - 20 )
GAL11 GCN5 HFI1 JEN1 MED1 MED11 MED2 MED4 MED6 MED7
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Topics Genes linked to topics (#21 - 30 )
MED8 NGG1 NUT1 NUT2 OAF1 PGD1 PIP2 POL2 POT1 POX1
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Topics Genes linked to topics (#31 - 40 )
RGR1 ROX3 RPO21 RTT102 SGF11 SIN4 SNF1 SNF11 SNF12 SNF2
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Topics Genes linked to topics (#41 - 50 )
SNF5 SNF6 SOH1 SPS19 SPT20 SPT3 SPT7 SPT8 SRB2 SRB4
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Topics Genes linked to topics (#51 - 60 )
SRB5 SRB6 SRB7 SSN2 SWI1 SWI3 SWP82 TAF10 TAF12 TAF14
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Topics Genes linked to topics (#61 - 65 )
TAF5 TAF6 TAF9 TRA1 UBP8
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