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Ehrentraut S, et al.  (2010) Rpd3-dependent boundary formation at telomeres by removal of Sir2 substrate. Proc Natl Acad Sci U S A 107(12):5522-7

Abstract: Boundaries between euchromatic and heterochromatic regions until now have been associated with chromatin-opening activities. Here, we identified an unexpected role for histone deacetylation in this process. Significantly, the histone deacetylase (HDAC) Rpd3 was necessary for boundary formation in Saccharomyces cerevisiae. rpd3 led to silent information regulator (SIR) spreading and repression of subtelomeric genes. In the absence of a known boundary factor, the histone acetyltransferase complex SAS-I, rpd3 caused inappropriate SIR spreading that was lethal to yeast cells. Notably, Rpd3 was capable of creating a boundary when targeted to heterochromatin. Our data suggest a mechanism for boundary formation whereby histone deacetylation by Rpd3 removes the substrate for the HDAC Sir2, so that Sir2 no longer can produce O-acetyl-ADP ribose (OAADPR) by consumption of NAD(+) in the deacetylation reaction. In essence, OAADPR therefore is unavailable for binding to Sir3, preventing SIR propagation.

Status: Published Type: Journal Article PubMed ID: 20133733

Topics addressed in this paper

Number of different genes curated to this paper: 16

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
DEP1 HHF1 HHF2 HHT1 HHT2 IRC7 RPD3 SAS2 SAS4 SAS5
Additional Literature blue ball blue ball
Cellular Location blue ball
Function/Process blue ball blue ball
Genetic Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Omics yg ball
Primary Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein Sequence Features blue ball blue ball blue ball blue ball
Protein-Nucleic Acid Interactions blue ball
Regulation of blue ball
RNA Levels and Processing blue ball
Strains/Constructs blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Transcription blue ball

Topics Genes linked to topics (#11 - 16 )
SDS3 SET2 SIR1 SIR2 SIR3 SIR4
Additional Literature blue ball blue ball blue ball blue ball
Cellular Location blue ball blue ball
Genetic Interactions blue ball blue ball blue ball blue ball blue ball
Genomic co-immunoprecipitation study blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball
Primary Literature blue ball blue ball
Protein/Nucleic Acid Structure blue ball
Strains/Constructs blue ball blue ball blue ball blue ball blue ball blue ball

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