SGD Paper 
Zhong P and Melcher K (2010) Identification and characterization of the activation domain of Ifh1, an activator of model TATA-less genes. Biochem Biophys Res Commun 392(1):77-82
Abstract: In yeast, TATA box-binding protein TBP can be delivered to protein-coding genes by direct interactions with two different coactivators: TFIID, which delivers TBP preferentially to TATA-less promoters, and SAGA, which strongly favors TATA box-containing promoters. Transcriptional activators of SAGA-dependant genes are characterized by prototypic acidic activation domains (ADs) that efficiently recruit SAGA, but not TFIID, to UAS elements even in the absence of a core promoter. In contrast to the well-studied acidic activation domains, little is known about the activation domains of activators of TFIID-dependent genes, even though these genes constitute more than 80% of eukaryotic protein-coding genes. The paradigm for TATA-less genes are the ribosomal protein genes (RPGs). Here we have identified the AD of the RPG activator Ifh1p and demonstrate that a minimal Ifh1 AD represents a new class of AD that significantly differs from acidic ADs in amino acid signature, relative coactivator affinities, and core promoter selectivity.CI - Copyright (c) 2010 Elsevier Inc. All rights reserved.
| Status: Published | Type: Journal Article | PubMed ID: 20059977 |
Topics addressed in this paper
Number of different genes curated to this paper: 10
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| Topics | Genes linked to topics | |||||||||
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| ADA2 | EAF6 | EPL1 | GAL1 | GAL4 | IFH1 | MED6 | RPS5 | SNF12 | TAF4 | |
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