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Rabut G and Peter M  (2008) Function and regulation of protein neddylation. 'Protein modifications: beyond the usual suspects' review series. EMBO Rep 9(10):969-76

Abstract: Neddylation is the post-translational protein modification that is most closely related to ubiquitination. However, ubiquitination is known to regulate a myriad of processes in eukaryotic cells, whereas only a limited number of neddylation substrates have been described to date. Here, we review the principles of protein neddylation and highlight the mechanisms that ensure the specificity of neddylation over ubiquitination. As numerous neddylation substrates probably remain to be discovered, we propose some criteria that could be used as guidelines for the characterization of neddylated proteins.

Status: Published Type: Journal Article | Review PubMed ID: 18802447

Topics addressed in this paper

Number of different genes curated to this paper: 17

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Topics Genes linked to topics (#1 - 10 )
CDC53 CSI1 CSN9 CUL3 DCN1 HRT1 PCI8 RRI1 RRI2 RTT101
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Topics Genes linked to topics (#11 - 17 )
RUB1 SKP1 UBA3 UBC12 ULA1 YJR084W YUH1
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