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Kanki T, et al.  (2009) A genomic screen for yeast mutants defective in selective mitochondria autophagy. Mol Biol Cell 20(22):4730-8

Abstract: Mitophagy is the process of selective mitochondrial degradation via autophagy, which has an important role in mitochondrial quality control. Very little is known, however, about the molecular mechanism of mitophagy. A genome-wide yeast mutant screen for mitophagy-defective strains identified 32 mutants with a block in mitophagy, in addition to the known autophagy-related (ATG) gene mutants. We further characterized one of these mutants, ylr356wDelta that corresponds to a gene whose function has not been identified. YLR356W is a mitophagy-specific gene that was not required for other types of selective autophagy or macroautophagy. The deletion of YLR356W partially inhibited mitophagy during starvation, whereas there was an almost complete inhibition at post-log phase. Accordingly, we have named this gene ATG33. The new mutants identified in this analysis will provide a useful foundation for researchers interested in the study of mitochondrial homeostasis and quality control.

Status: Published Type: Journal Article | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't PubMed ID: 19793921

Topics addressed in this paper

Number of different genes curated to this paper: 51

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
AIM26 ARG82 ARO2 ATG1 ATG10 ATG11 ATG12 ATG13 ATG16 ATG17
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Large-scale phenotype analysis yg ball
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Omics yg ball
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Topics Genes linked to topics (#11 - 20 )
ATG2 ATG20 ATG21 ATG29 ATG3 ATG31 ATG32 ATG33 ATG4 ATG5
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Topics Genes linked to topics (#21 - 30 )
ATG7 ATG8 ATG9 BCK1 BUB1 CCZ1 DNM1 EGD1 FCJ1 FMC1
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Topics Genes linked to topics (#31 - 40 )
HUR1 ICY2 MAK10 MFM1 MON1 NFT1 PEP12 PEP4 PMR1 RPL13B
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Topics Genes linked to topics (#41 - 50 )
RPL14A RPL15B SNX4 TRS85 VAM7 VPS36 VPS41 YIL165C YOR019W YPR146C
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Topics Genes linked to topics (#51 )
YPT7
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