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Ohtsuki K, et al.  (2010) Genome-wide localization analysis of a complete set of Tafs reveals a specific effect of the taf1 mutation on Taf2 occupancy and provides indirect evidence for different TFIID conformations at different promoters. Nucleic Acids Res 38(6):1805-20

Abstract: In Saccharomyces cerevisiae, TFIID and SAGA principally mediate transcription of constitutive housekeeping genes and stress-inducible genes, respectively, by delivering TBP to the core promoter. Both are multi-protein complexes composed of 15 and 20 subunits, respectively, five of which are common and which may constitute a core sub-module in each complex. Although genome-wide gene expression studies have been conducted extensively in several TFIID and/or SAGA mutants, there are only a limited number of studies investigating genome-wide localization of the components of these two complexes. Specifically, there are no previous reports on localization of a complete set of Tafs and the effects of taf mutations on localization. Here, we examine the localization profiles of a complete set of Tafs, Gcn5, Bur6/Ncb2, Sua7, Tfa2, Tfg1, Tfb3 and Rpb1, on chromosomes III, IV and V by chromatin immunoprecipitation (ChIP)-chip analysis in wild-type and taf1-T657K mutant strains. In addition, we conducted conventional and sequential ChIP analysis of several ribosomal protein genes (RPGs) and non-RPGs. Intriguingly, the results revealed a novel relationship between TFIIB and NC2, simultaneous co-localization of SAGA and TFIID on RPG promoters, specific effects of taf1 mutation on Taf2 occupancy, and an indirect evidence for the existence of different TFIID conformations.

Status: Published Type: Journal Article PubMed ID: 20026583

Topics addressed in this paper

Number of different genes curated to this paper: 68

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ARF1 BAP3 BUR6 CDC48 CDC53 CDC9 COP1 CYK3 DLD3 DOS2
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Genomic co-immunoprecipitation study yg ball
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Topics Genes linked to topics (#11 - 20 )
GCN5 HEM12 HNT1 HTB1 IPT1 LDB17 MHF2 NCB2 NOP14 NRP1
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Topics Genes linked to topics (#21 - 30 )
OCA6 PET100 RPL10 RPL27B RPL31A RPL35A RPL35B RPL41B RPL4B RPN5
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Topics Genes linked to topics (#31 - 40 )
RPO21 RPP1B RPS11A RPS13 RPS17B RRG1 SED1 SHU2 SLU7 SNA4
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Topics Genes linked to topics (#41 - 50 )
SNF11 SSS1 STE7 SUA7 TAF1 TAF10 TAF11 TAF12 TAF13 TAF14
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Topics Genes linked to topics (#51 - 60 )
TAF2 TAF3 TAF4 TAF5 TAF6 TAF7 TAF8 TAF9 TFA2 TFB3
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Protein-Nucleic Acid Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#61 - 68 )
TFB5 TFG1 TPS2 TRT2 UGA3 VPS41 YCL049C YDR089W
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