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Vanoosthuyse V and Hardwick KG (2009) Overcoming inhibition in the spindle checkpoint. Genes Dev 23(24):2799-805
Abstract: Spindle checkpoint silencing is a critical step during mitosis that initiates chromosome segregation, yet surprisingly little is known about its mechanism. Protein phosphatase I (PP1) was shown recently to be a key player in this process, and in this issue of Genes & Deverlopment, Akiyoshi and colleagues (pp. 2887-2899) identify budding yeast Fin1p as a kinetochore-localized regulator of PP1 activity toward checkpoint targets. Here we review recent mechanistic insights and propose a working model for spindle checkpoint silencing.
| Status: Published | Type: Comment | Journal Article | Research Support, Non-U.S. Gov't | Review | PubMed ID: 20008930 |
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