Takara TJ and Bell SP (2009) Putting two heads together to unwind DNA. Cell 139(4):652-4
Abstract: The loading of replicative helicases onto DNA is tightly regulated in all organisms, yet the molecular mechanisms for this event remain poorly defined. Remus et al. (2009) provide important insights into helicase loading in eukaryotes, showing that the Mcm2-7 replicative helicase encircles double-stranded DNA as head-to-head double hexamers.
|Status: Published||Type: Comment | Journal Article | Research Support, Non-U.S. Gov't||PubMed ID: 19914158|
Topics addressed in this paper
Number of different genes curated to this paper: 7
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