SGD Paper 
Fontanesi F, et al. (2010) Mss51 and ssc1 facilitate translational regulation of cytochrome C oxidase biogenesis. Mol Cell Biol 30(1):245-59
Abstract: The intricate biogenesis of multimeric organellar enzymes of dual genetic origin entails several levels of regulation. In S. cerevisiae, mitochondrial cytochrome c oxidase (COX) assembly is regulated translationally. Synthesis of subunit 1 (Cox1) is contingent on the availability of its assembly partners, thereby acting as a negative feedback loop that coordinates COX1 mRNA translation with Cox1 utilization during COX assembly. The COX1 mRNA specific translational activator Mss51 plays a fundamental role in this process. Here we report that Mss51 successively interacts with the COX1 mRNA translational apparatus, newly synthesized Cox1 and other COX assembly factors during Cox1 maturation/assembly. Notably, the mitochondrial Hsp70 chaperone Ssc1 is shown to be an Mss51 partner throughout its metabolic cycle. We conclude that Ssc1, by interacting with Mss51 and Mss51-containing complexes, plays a critical role in Cox1 biogenesis, COX assembly and the translational regulation of these processes.
| Status: Published | Type: Journal Article | PubMed ID: 19858289 |
Topics addressed in this paper
Number of different genes curated to this paper: 10
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