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Chen T and Li F  (2009) Identifying cell cycle regulators and combinatorial interactions among transcription factors with microarray data and ChIP-chip data. Int J Bioinform Res Appl 5(6):625-46

Abstract: In this paper, we integrate transcriptional regulatory modelling with temporal correlation analysis between one Transcription Factor (TF) and its corresponding cell cycle-regulated targets to investigate Cell Cycle Regulators (CCRs) and combinatorial interactions among TFs across the cell cycle in Saccharomyces cerevisiae. Our method is developed based on the rationale that if one TF or one TF combinatorial interaction takes more possibilities of sharing common cell cycle-regulated targets with other TFs, this TF or TF combinatorial interaction is more likely to control the cell cycle. Our results reveal abundant CCRs and TF co-operativities supported by biological experiments or other computational methods.

Status: Published Type: Journal Article PubMed ID: 19887337

Topics addressed in this paper

Number of different genes curated to this paper: 28

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ABF1 ACE2 CIN5 DAT1 FHL1 FKH1 FKH2 HAP4 IXR1 MBP1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cell Cycle Phase Involved blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Computational analysis yg ball
Omics yg ball
Regulatory Role blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#11 - 20 )
MCM1 NDD1 NRG1 PDR1 PHD1 RAP1 RLM1 RPN4 SMP1 STB1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cell Cycle Phase Involved blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Regulatory Role blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#21 - 28 )
STP1 SWI4 SWI5 SWI6 TEC1 YAP5 YAP6 YOX1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cell Cycle Phase Involved blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Regulatory Role blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

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