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Vogtle FN, et al.  (2009) Global analysis of the mitochondrial N-proteome identifies a processing peptidase critical for protein stability. Cell 139(2):428-39

Abstract: Many mitochondrial proteins are synthesized with N-terminal presequences that are removed by specific peptidases. The N-termini of the mature proteins and thus peptidase cleavage sites have only been determined for a small fraction of mitochondrial proteins and yielded a controversial situation for the cleavage site specificity of the major mitochondrial processing peptidase (MPP). We report a global analysis of the N-proteome of yeast mitochondria, revealing the N-termini of 615 different proteins. Significantly more proteins than predicted contained cleavable presequences. We identified the intermediate cleaving peptidase Icp55, which removes an amino acid from a characteristic set of MPP-generated N-termini, solving the controversial situation of MPP specificity and suggesting that Icp55 converts instable intermediates into stable proteins. Our results suggest that Icp55 is critical for stabilization of the mitochondrial proteome and illustrate how the N-proteome can serve as rich source for a systematic analysis of mitochondrial protein targeting, cleavage and turnover.

Status: Published Type: Journal Article | Research Support, Non-U.S. Gov't PubMed ID: 19837041

Topics addressed in this paper

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ACO1 ACP1 AIM17 AIM36 ALD4 ALT1 ATP11 ATP16 ATP17 ATP3
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Omics yg ball
Other large-scale proteomic analysis yg ball
Protein Processing/Modification/Regulation blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#11 - 20 )
CIT1 COR1 COX11 COX6 DLD2 EMI5 FMP10 FMP16 GRX2 HSP60
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein Processing/Modification/Regulation blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein Sequence Features blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#21 - 30 )
ICP55 IDH2 INH1 LAT1 LYS12 MAE1 MAS1 MAS2 MGE1 MRP20
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Cellular Location blue ball
Function/Process blue ball
Mutants/Phenotypes blue ball
Primary Literature blue ball
Protein Processing/Modification/Regulation blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein Sequence Features blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#31 - 40 )
MRPL11 MSF1 MSK1 MSY1 PAM17 PDB1 PUT2 RDL2 RSM28 STF1
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Protein Processing/Modification/Regulation blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#41 )
TIM21
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