SGD Paper Help


Page Contents:
Ghazal G, et al.  (2009) Yeast RNase III triggers polyadenylation-independent transcription termination. Mol Cell 36(1):99-109

Abstract: Transcription termination of messenger RNA (mRNA) is normally achieved by polyadenylation followed by Rat1p-dependent 5'-3' exoribonuleolytic degradation of the downstream transcript. Here we show that the yeast ortholog of the dsRNA-specific ribonuclease III (Rnt1p) may trigger Rat1p-dependent termination of RNA transcripts that fail to terminate near polyadenylation signals. Rnt1p cleavage sites were found downstream of several genes, and the deletion of RNT1 resulted in transcription readthrough. Inactivation of Rat1p impaired Rnt1p-dependent termination and resulted in the accumulation of 3' end cleavage products. These results support a model for transcription termination in which cotranscriptional cleavage by Rnt1p provides access for exoribonucleases in the absence of polyadenylation signals.

Status: Published Type: Journal Article | Research Support, Non-U.S. Gov't PubMed ID: 19818713

Topics addressed in this paper

Number of different genes curated to this paper: 44

Jump to Summary Chart for:
  • To find other papers on a gene and topic, click on the colored ball in the appropriate box.
  • displays other papers with information about that topic for that gene.
  • displays other papers in SGD that are associated with that topic.
    The topic is addressed in these papers but does not describe a specific gene or chromosomal feature.
  • To go to the Locus page for a gene, click on the gene name.
Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
CDC19 CSR1 FTR1 GIC2 GPI17 LGE1 LYP1 MED7 MIC17 MRH1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Alias blue ball
Genomic co-immunoprecipitation study yg ball
Mutants/Phenotypes blue ball
Omics yg ball
Primary Literature blue ball blue ball
Protein Processing/Modification/Regulation blue ball
Regulation of blue ball
RNA Levels and Processing blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Strains/Constructs blue ball
Transcription blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#11 - 20 )
NAB2 NAM7 NCB2 NOP1 NPL3 NPL4 OPI6 OTU1 PRE6 PTC2
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Alias blue ball
DNA/RNA Sequence Features blue ball blue ball
Mutants/Phenotypes blue ball blue ball
Primary Literature blue ball blue ball
Protein Processing/Modification/Regulation blue ball
RNA Levels and Processing blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Strains/Constructs blue ball blue ball
Transcription blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#21 - 30 )
RAT1 RIB1 RNT1 RPL27A RPL27B RPL40A RPL8A RPN12 RPO21 RPP1A
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Alias blue ball
DNA/RNA Sequence Features blue ball
Function/Process blue ball
Genetic Interactions blue ball
Mutants/Phenotypes blue ball blue ball
Primary Literature blue ball blue ball blue ball
Protein-Nucleic Acid Interactions blue ball
RNA Levels and Processing blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Strains/Constructs blue ball blue ball
Substrates/Ligands/Cofactors blue ball blue ball
Transcription blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Jump to Summary Chart for:
  • To find other papers on a gene and topic, click on the colored ball in the appropriate box.
  • displays other papers with information about that topic for that gene.
  • displays other papers in SGD that are associated with that topic.
    The topic is addressed in these papers but does not describe a specific gene or chromosomal feature.
  • To go to the Locus page for a gene, click on the gene name.

Topics Genes linked to topics (#31 - 40 )
RPS14B RRP1 RRP6 SBA1 SIM1 SNR190 SUT1 TEF2 TOS1 TPI1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball
RNA Levels and Processing blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Strains/Constructs blue ball
Substrates/Ligands/Cofactors blue ball
Transcription blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#41 - 44 )
XRN1 YKU80 YPS3 ZEO1
Additional Literature blue ball blue ball blue ball
Alias blue ball
Genetic Interactions blue ball
Mutants/Phenotypes blue ball
Primary Literature blue ball
RNA Levels and Processing blue ball blue ball blue ball
Strains/Constructs blue ball
Transcription blue ball blue ball blue ball

Author Searches

To find contact information or other publications by the authors of this paper, follow these three steps:
  1. (1) Choose an author,
  2. (2) Choose a search parameter,
  3. (3) Click to implement
Page Contents: