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Ginsburg DS, et al.  (2009) NuA4 Lysine Acetyltransferase Esa1 Is Targeted to Coding Regions and Stimulates Transcription Elongation with Gcn5. Mol Cell Biol 29(24):6473-87

Abstract: NuA4, the major H4 acetyltransferase (KAT) complex in budding yeast, is recruited to promoters and stimulates transcription initiation. NuA4 subunits contain domains that bind methylated histones, suggesting that histone methylation should target NuA4 to coding sequences during transcription elongation. We show that NuA4 is co-transcriptionally recruited dependent on its physical association with elongating Pol II phosphorylated on the CTD by CDK7/Kin28, but independent of subunits (Eaf1 and Tra1) required for NuA4 recruitment to promoters. Whereas histone methylation by Set1 and Set2 is dispensable for NuA4's interaction with Pol II and targeting to some coding regions, it stimulates NuA4-histone interaction and H4 acetylation in vivo. The NuA4 KAT, Esa1, mediates increased H4 acetylation, enhanced RSC occupancy and histone eviction in coding sequences, and stimulates the rate of transcription elongation. Esa1 cooperates with the H3 KAT in SAGA, Gcn5, to enhance these functions. Our findings delineate a pathway for acetylation-mediated nucleosome remodeling and eviction in coding sequences that stimulates transcription elongation by Pol II in vivo.

Status: Published Type: Journal Article PubMed ID: 19822662

Topics addressed in this paper

Number of different genes curated to this paper: 24

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Topics Genes linked to topics (#1 - 10 )
EAF1 EAF3 EAF5 EAF7 EPL1 ESA1 FMP27 GCN5 HDA1 HHF1
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Topics Genes linked to topics (#11 - 20 )
HHF2 HOS2 KIN28 PHO5 RPB3 RPD3 RPO21 RSC1 RSC2 SET1
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Topics Genes linked to topics (#21 - 24 )
SET2 SNF6 STH1 TRA1
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