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Fontanesi F, et al.  (2009) Evaluation of the mitochondrial respiratory chain and oxidative phosphorylation system using yeast models of OXPHOS deficiencies. Curr Protoc Hum Genet Chapter 19:Unit19.5

Abstract: The oxidative phosphorylation (OXPHOS) system consists of five multimeric complexes embedded in the mitochondrial inner membrane. They work in concert to drive the aerobic synthesis of ATP. Mitochondrial and nuclear DNA mutations affecting the accumulation and function of these enzymes are the most common cause of mitochondrial diseases and have also been associated with neurodegeneration and aging. Several approaches for the assessment of the OXPHOS system enzymes have been developed. Based on the methods described elsewhere, this unit describes the creation and study of yeast models of mitochondrial OXPHOS deficiencies.

Status: Published Type: Journal Article | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't PubMed ID: 19806592

Topics addressed in this paper

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Topics Genes linked to topics (#1 - 10 )
ATM1 ATP6 BCS1 COX12 EMI5 ERV1 LSC1 MEF1 MIP1 MIR1
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Topics Genes linked to topics (#11 - 20 )
ORT1 PET9 PIC2 SDH2 SOD1 SYM1 TAZ1 TIM8 TUF1 YDR379C-A
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Topics Genes linked to topics (#21 )
YFH1
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