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Cole KC, et al.  (2009) Multiple proteins and phosphorylations regulate Saccharomyces cerevisiae Cdc24p localization. FEBS Lett 583(20):3339-43

Abstract: Targeting of Saccharomyces cerevisiae Cdc24p to polarized growth sites is essential for its function. Localization of GFP-tagged Cdc24 proteins or fragments was assayed in deletion mutants of Cdc24p-interacting proteins. The boi2Delta, ent2Delta, and hua1Delta mutants showed localization defects. The tos2Delta skg6Delta double mutant displayed aberrant pre-anaphase localization to the mother-bud neck region. The same aberrant pattern was seen when potential phosphorylation sites Ser697, Thr704, and Tyr200 were mutated. The S697A mutation also resulted in phosphorylation defects in vivo. These data support roles for Boi2p, Ent2p, Hua1p, Tos2p, and for Cdc24p phosphorylation in targeting Cdc24p to growth sites.

Status: Published Type: Journal Article PubMed ID: 19782078

Topics addressed in this paper

Number of different genes curated to this paper: 11

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Topics Genes linked to topics (#1 - 10 )
AIR1 AKR1 BOI1 BOI2 CDC24 ENT1 ENT2 HUA1 SHE2 SKG6
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Topics Genes linked to topics (#11 )
TOS2
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