Carroll CW and Straight AF (2006) Centromere formation: from epigenetics to self-assembly. Trends Cell Biol 16(2):70-8
Abstract: This review is part of the Chromosome segregation and Aneuploidy series that focuses on the importance of chromosome segregation mechanisms in maintaining genome stability. Centromeres are specialized chromosomal domains that serve as the foundation for the mitotic kinetochore, the interaction site between the chromosome and the mitotic spindle. The chromatin of centromeres is distinguished from other chromosomal loci by the unique incorporation of the centromeric histone H3 variant, centromere protein A. Here, we review the genetic and epigenetic factors that control the formation and maintenance of centromeric chromatin and propose a chromatin self-assembly model for organizing the higher-order structure of the centromere.
|Status: Published||Type: Journal Article | Review||PubMed ID: 16412639|
Topics addressed in this paper
Number of different genes curated to this paper: 19
- To go to the Locus page for a gene, click on the gene name.
|Topics||Genes (#11 - 19 )|
|Fungal Related Genes/Proteins|
|Non-Fungal Related Genes/Proteins|