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Somers J and Owen-Hughes T  (2009) Mutations to the histone H3 alpha N region selectively alter the outcome of ATP-dependent nucleosome-remodelling reactions. Nucleic Acids Res 37(8):2504-13

Abstract: Mutational analysis of the histone H3 N-terminal region has shown it to play an important role both in chromatin function in vivo and nucleosome dynamics in vitro. Here we use a library of mutations in the H3 N-terminal region to investigate the contribution of this region to the action of the ATP-dependent remodelling enzymes Chd1, RSC and SWI/SNF. All of the enzymes were affected differently by the mutations with Chd1 being affected the least and RSC being most sensitive. In addition to affecting the rate of remodelling by RSC, some mutations prevented RSC from moving nucleosomes to locations in which DNA was unravelled. These observations illustrate that the mechanisms by which different ATP-dependent remodelling enzymes act are sensitive to different features of nucleosome structure. They also show how alterations to histones can affect the products generated as a result of ATP-dependent remodelling reactions.

Status: Published Type: Journal Article | Research Support, Non-U.S. Gov't PubMed ID: 19264807

Topics addressed in this paper

Number of different genes curated to this paper: 29

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Topics Genes linked to topics (#1 - 10 )
ARP7 ARP9 CHD1 HHT1 HHT2 HTL1 LDB7 NPL6 RSC1 RSC2
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Topics Genes linked to topics (#11 - 20 )
RSC3 RSC30 RSC4 RSC58 RSC6 RSC8 RSC9 RTT102 SFH1 SNF11
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Topics Genes linked to topics (#21 - 29 )
SNF12 SNF2 SNF5 SNF6 STH1 SWI1 SWI3 SWP82 TAF14
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