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Scheifele LZ, et al.  (2009) Retrotransposon overdose and genome integrity. Proc Natl Acad Sci U S A 106(33):13927-32

Abstract: Yeast and mammalian genomes are replete with nearly identical copies of long dispersed repeats in the form of retrotransposons. Mechanisms clearly exist to maintain genome structure in the face of potential rearrangement between the dispersed repeats, but the nature of this machinery is poorly understood. Here we describe a series of distinct "retrotransposon overdose" (RO) lineages in which the number of Ty1 elements in the Saccharomyces cerevisiae genome has been increased by as much as 10 fold. Although these RO strains are remarkably normal in growth rate, they demonstrate an intrinsic supersensitivity to DNA-damaging agents. We describe the identification of mutants in the DNA replication pathway that enhance this RO-specific DNA damage supersensitivity by promoting ectopic recombination between Ty1 elements. Abrogation of normal DNA replication leads to rampant genome instability primarily in the form of chromosomal aberrations and confirms the central role of DNA replication accuracy in the stabilization of repetitive DNA.

Status: Published Type: Journal Article PubMed ID: 19666515

Topics addressed in this paper

Number of different genes curated to this paper: 59

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Topics Genes linked to topics (#1 - 10 )
CSM3 CTF18 CTF4 CTF8 DCC1 DIA2 ELG1 ESC2 HST1 HST3
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#11 - 20 )
HTZ1 MRC1 MUS81 NPT1 POL1 POL32 RAD17 RAD27 RAD6 RPN4
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Strains/Constructs blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#21 - 30 )
RRM3 RSC1 SGS1 SLX5 SLX8 SPT3 SRS2 TOF1 YARCTy1-1 YBLWTy1-1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Alias blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Other Features blue ball blue ball
Strains/Constructs blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#31 - 40 )
YBRWTy1-2 YDRCTy1-1 YDRCTy1-2 YDRCTy1-3 YDRWTy1-4 YDRWTy1-5 YERCTy1-1 YERCTy1-2 YGRCTy1-2 YGRCTy1-3
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Other Features blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Strains/Constructs blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#41 - 50 )
YGRWTy1-1 YHRCTy1-1 YJRWTy1-1 YJRWTy1-2 YLRCTy1-1 YLRWTy1-2 YLRWTy1-3 YMLWTy1-1 YMLWTy1-2 YMRCTy1-3
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Other Features blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Strains/Constructs blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#51 - 59 )
YMRCTy1-4 YNLCTy1-1 YNLWTy1-2 YOLWTy1-1 YORWTy1-2 YPLWTy1-1 YPRCTy1-2 YPRCTy1-4 YPRWTy1-3
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Other Features blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Strains/Constructs blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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  • To find other papers on a gene and topic, click on the colored ball in the appropriate box.
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    The topic is addressed in these papers but does not describe a specific gene or chromosomal feature.
  • To go to the Locus page for a gene, click on the gene name.

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