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Putnam CD, et al.  (2009) Specific pathways prevent duplication-mediated genome rearrangements. Nature 460(7258):984-9

Abstract: We have investigated the ability of different regions of the left arm of Saccharomyces cerevisiae chromosome V to participate in the formation of gross chromosomal rearrangements (GCRs). We found that the 4.2-kilobase HXT13-DSF1 region sharing divergent homology with chromosomes IV, X and XIV, similar to mammalian segmental duplications, was 'at risk' for participating in duplication-mediated GCRs generated by homologous recombination. Numerous genes and pathways, including SGS1, TOP3, RMI1, SRS2, RAD6, SLX1, SLX4, SLX5, MSH2, MSH6, RAD10 and the DNA replication stress checkpoint requiring MRC1 and TOF1, were highly specific for suppressing these GCRs compared to GCRs mediated by single-copy sequences. These results indicate that the mechanisms for formation and suppression of rearrangements occurring in regions containing at-risk sequences differ from those occurring in regions of single-copy sequence. This explains how extensive genome instability is prevented in eukaryotic cells whose genomes contain numerous divergent repeated sequences.

Status: Published Type: Journal Article PubMed ID: 19641493

Topics addressed in this paper

Number of different genes curated to this paper: 43

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Topics Genes linked to topics (#1 - 10 )
ARP8 CHK1 CTF18 DSF1 DUN1 ESC2 EXO1 HXT13 MEC1 MLH1
DNA/RNA Sequence Features blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#11 - 20 )
MPH1 MRC1 MRE11 MSH2 MSH3 MSH6 MUS81 NHP10 POL12 POL32
Genetic Interactions blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#21 - 30 )
PRE2 RAD10 RAD24 RAD27 RAD51 RAD52 RAD53 RAD59 RAD6 RAD9
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Topics Genes linked to topics (#31 - 40 )
RMI1 RRM3 RTT107 SAE2 SGS1 SLX1 SLX4 SLX5 SLX8 SRS2
Genetic Interactions blue ball
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Topics Genes linked to topics (#41 - 43 )
TEL1 TOF1 TOP3
Mutants/Phenotypes blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball
Strains/Constructs blue ball blue ball blue ball

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