Noubhani A, et al. (2009) The trehalose pathway regulates mitochondrial respiratory chain content through hexokinase 2 and cAMP in Saccharomyces cerevisiae. J Biol Chem 284(40):27229-34
Abstract: In yeast, trehalose is synthesized by a multimeric enzymatic complex: TPS1 encodes trehalose-6-P (Tre6P) synthase which belongs to a complex that is composed of at least three other subunits, including Tre6P phosphatase Tps2 and the redundant regulatory subunits Tps3 and Tsl1. The product of the TPS1 gene plays an essential role in the control of the glycolytic pathway by restricting the influx of glucose into glycolysis. In this paper, we investigated whether the trehalose synthesis pathway could be involved in the control of the other energy-generating pathway: oxidative phosphorylation. We show that the different mutants of the trehalose synthesis pathway (tps1, tps2, tps1,2) exhibit modulation in the amount of respiratory chains, in terms of cytochrome content and maximal respiratory activity. Furthermore, these variations in mitochondrial enzymatic content are positively linked to the intracellular concentration in cAMP that is modulated by Tps1p through hexokinase2. This is the first time that a pathway involved in sugar storage i.e. trehalose is shown to regulate the mitochondrial enzymatic content.
|Status: Published||Type: Journal Article||PubMed ID: 19620241|
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